"Our team is engaged in the development of polymeric carrier systems to serve as a carrier matrix of low bioavailability drugs. Carrier systems should primarily serve for the targeted delivery of chemotherapeutics. An integral part is the design and development of the matrix to be biodegradable and to provide controlled or targeted release of the carried substance. We observe physicochemical parameters in relation to hydrodynamic size, compatibility with the supported substance or stability in different environments in developed materials.
In cooperation with other research groups, we also participate in their analytical characterization and in vitro biological testing. In cooperation with external workplaces, we are involved in in-vivo experiments planning that tests the efficiency and functionality of carrier systems. Besides the development of carrier systems, our team provides structural analysis (NMR spectroscopy), thermal (TG, DSC, ITC) and selected rheological analyses for our colleagues from other R&D departments.
We also take part in solving problems in transferring new products from the laboratory to production. Our team is actively involved in preparing documents for publication, patent and project outputs. Thanks to the broad-based focus of our team, our employees are exposed to diverse activities and have insight into a number of areas of new application trends."
Ing. Daniela Šmejkalová, Ph.D., Head of Polymeric Carrier Systems Team
Methods and technical background:
Equipment for characterization of our carrier systems:
- NMR, LC-MS, HPLC-DAD, TG, DSC, ITC, etc.
Equipment for the life-science field:
- qRT-PCR
- DNA array
- Electrophoresis
- Western blotting
- Flow cytometry
- Fluorescence confocal microscopy
Key tasks and responsibilities:
- Development of hyaluronic acid-based hydrogel materials for the field of polymeric carrier drugs
- Design and development of matrix carrier systems for targeted drug distribution
- Design and development of matrix carrier systems for controlled drug distribution
- Physical and chemical characterization of developed systems
What do we require?
- Tertiary education (Ph.D.) graduated in Chemistry of Materials, Physical Chemistry, Polymer Chemistry, Biopolymers, Consumer Chemistry or similar fields
- Experience in a similar position necessary
- Excellent orientation in scientific literature
- Knowledge of English (minimal level B2)
- Good knowledge of PC work with MS Office programs
- Ability to work in a team
- Responsibility, independence, thoroughness
- Interest in solving complex and multidisciplinary tasks
What do we offer?
- Support of personal development and education
- Flexible working hours with the ability to maximize harmonization of work and personal activities
- Foreign business trips
- One week of extra holidays after one year (overall 5 weeks)
- Background of a stable company with a tradition of more than 25 years in world markets
- Subsidized catering inside the company
- Financial contributions for children's recreation
- Discount on company products
- Interest-free housing loans
- Assistance in obtaining accommodation and loans for the purchase of own housing
