Research and development

The fermentation research team focuses on the study of microorganisms and the application of fermentation processes for the production of bioactive substances. Its main area of interest is innovation in the production process of hyaluronic acid. The model microorganism is the bacterium Streptococcus zooepidemicus, a natural producer of hyaluronic acid. The group studies its genetic background, nutritional requirements and optimal cultivation conditions in order to fully use its production potential. Its facilities allow the group to introduce and optimise bioprocesses. It also prepares laboratory specialities for R&D purposes, such as 13C-HA and recombinant hyaluronidases, which may be offered through an e-shop. In addition, the group provides advanced services to customers and cooperating research institutions.

This research team focuses on the development and synthesis of polysaccharide and peptide derivatives on a scale ranging from 10 mg to 5 kg. Emphasis is placed on the originality of the developed materials, which then serve as matrices or active substances for tissue engineering, cosmetics and wound healing. In some cases, their use can also be considered in the field of carriers for active pharmaceutical substances. We also synthesise low-molecular-weight substances, mainly for cosmetics, where strong emphasis is placed on process optimisation and efficiency. Product analysis is an important part of the work, both for research and production. We use advanced NMR, FTIR and chromatographic methods.

Research team of physical chemistry focuses on studying the physicochemical behaviour of biopolymers. It establishes relationships between composition, structure, processing and properties that can be used in various applications of hyaluronan and its derivatives. The group also develops carrier systems based on hydrophobised hyaluronan and studies their interactions with biomolecules and biological tissues. It uses physicochemical methods such as rheology, calorimetry, fluorescence and mechanical analysis to characterise unique Contipro products.

This research team focuses on basic and oriented research into the biology of hyaluronic acid. Its members study the biological effects of hyaluronic acid and its derivatives after administration into the organism. The safety of these substances is also tested using cell models, and the biological effects of substances and materials applied in vivo are analysed within collaborative projects. The group also studies the role of stem cells in regeneration and the use of hyaluronic acid in stem cell cryopreservation.

This research team focuses on skin ageing research and the influence of endogenous and exogenous factors on the structure, function and appearance of the skin. The aim is to identify biological targets for the development of innovative cosmetic ingredients. The group also carries out the complete development of raw materials, from the initial idea to market launch, including in vitro, ex vivo and in vivo testing of safety and efficacy as part of clinical studies on volunteers.

The Hydrogels and Films research team focuses on the development of advanced material forms of hyaluronan and its derivatives. The team explores how hyaluronic acid can be processed into hydrogels, thin films and other structures with properties suitable for specialized medical and pharmaceutical applications. These materials can serve, for example, as absorbable implants, carriers of active substances or support systems for regenerative medicine and tissue engineering. According to Contipro, hyaluronan-based forms may find use in areas such as wound healing, tissue engineering, viscosupplementation and adhesion prevention.

This research team focuses on the preparation of microfibres from hyaluronic acid and its derivatives. We use techniques such as wet spinning and spunbonding. The group works not only on fibre preparation, but also on their further processing into textile forms. Microfibres can be used to prepare knitted fabrics, gauzes, nonwovens and, last but not least, cotton-like materials. These textile forms find applications in the field of wound healing.

The nanofibre research team focuses on the research, development and preparation of nanofibrous layers using electrospinning. Nanofibres can be created from a wide range of materials, both hydrophobic and hydrophilic, depending on the required application and properties. At Contipro a.s., we focus primarily on electrospinning HA and its hydrophobised derivatives, with application potential in medicine, cosmetics, such as nanofibre masks, and filtration systems for respiratory protection. A characteristic feature of nanofibres is their high specific surface area, porosity and ability to form a matrix for a wide range of active substances that can be incorporated into their structure.

This research team focuses on the characterisation of hyaluronan derivatives and their pharmacokinetics. It studies how active substances are absorbed, distributed, metabolised and excreted after administration, as well as how they affect the organism and interact with tissues. The aim is to optimise their therapeutic use. The research is based primarily on advanced mass spectrometry methods.

This research team focuses on the development of innovative dietary supplements based on hyaluronic acid and other bioactive substances. It uses Contipro’s long-term know-how in the field of hyaluronan, including its properties, processing and application in final product forms. The group works on selecting suitable active ingredients, their combinations, dosage, stability and technological processability, so that the final products meet high standards for quality, safety and user acceptance.

The research team of technology focuses on the research and development of highly specialised equipment for new pharmaceutical and cosmetic products based on polymers, specifically thermolabile biopolymers and other biocompatible substances. We address complex challenges related to the lack of available technical solutions for creating new structures and forms of these materials. Our technologies also bridge the gap between laboratory research and small-scale production. They allow us to optimise automated processes and ensure the required high quality of final products. In this way, we bring innovative solutions that enable our colleagues to explore new biocompatible structures and forms, and to develop new products for modern health and beauty care.
Náš tým je složen z nadšených odborníků, kteří se denně věnují vývoji inovativních technologií. Kombinujeme znalosti z různých oblastí, jako je strojírenství, fyzika, materiálové inženýrství a informatika, abychom vytvořili unikátní řešení pro naše kolegy a partnery. Naše práce je pestrá a zahrnuje navrhování technických řešení, plánování experimentů, konstrukci zařízení, analýzu dat a optimalizaci procesů. Neustále sledujeme nejnovější trendy a technologie, abychom mohli nabídnout to nejlepší provedení. Každý člen našeho týmu je odborníkem ve svém oboru a zároveň týmovým hráčem, který přispívá k úspěchu celého projektu.