Schizophyllan demonstrates the effect on skin hydration of reducing transepidermal water loss, reflected in increased water retention in the epidermis.
Support for the viability of keratinocytes leads to their rapid proliferation, the faster restoration of the stratum corneum and increased production of precursors, which are the basis of lipids necessary for the proper functioning of the natural moisturizing factor. This enhances the barrier function of the stratum corneum, reducing TEWL.
The hydration capacity of hyaluronic acid is well known. As demonstrated in our in vivo study, the application of even high-molecular hyaluronic acid significantly increases water content in the skin. Although high-molecular acid does not penetrate the skin, its ability to create a highly hydrated film on the skin's surface radically decreases the TEWL and therefore helps to retain water in the skin.
HySilk's ability to improve skin hydration is based on two important properties. The first, due to its low molecular weight, is the capacity to penetrate into the lower layers of the stratum corneum, where its ability to actively influence cell communication processes, particularly the activity of beta-glucosylcerebrosidase, comes to the fore. The natural ability of hyaluronic acid to bind large quantities of water further supports these active processes, leading to a significant reduction in the TEWL.
Cellcon is a peptide designed to stimulate production of the desmosomal protein desmoglein-1, one of the main components of desmosomes, the specialized cell junction. By supporting the inter- and intracellular connection of keratinocyte epidermal cells, Cellcon helps to improve the integrity of the epidermis and enhances its biological functions