Application of Hyaluronan fragmentsThe properties of low-molecular weight Hyaluronan and Hyaluronan oligosaccharides predestine them for use in a wide range of therapeutic preparations.
Anti-cancer treatmentOne application is the targeted delivery of therapeutics for the treatment of tumour cells via cell receptors specific for low-molecular weight (LMW) Hyaluronan and Hyaluronan oligosaccharides. This approach reduces the side effects of chemotherapy and increases the effectiveness of the treatment. The reduction of cell barrier of tumour cells formed by high-molecular weight (HMW) Hyaluronan is enabled, thus the tumour cells are more sensitive to the delivered therapeutics. This is enabled due to the higher affinity of cell receptors to LMW Hyaluronan and Hyaluronan oligosaccharides in comparison with the affinity to the polyvalent molecule of high-molecular weight Hyaluronic acid. The problem of multi-drug resistance is suppressed due to the blocking of the MDR-responsible gene formation pathway with low molecular weight Hyaluronic Acid and Hyaluronan oligosaccharides.
Early phases of wound healingStrong pro-inflammatory and pro-angiogenetic properties of Hyaluronan and Hyaluronan oligosaccharides are utilised in early phases of wound healing. The initiation and the inflammatory phase are convenient for use of this product, whereas use of high-molecular weight form of hyaluronan is recommended in later stages of wound healing (granulation, epithelisation).
Use of low-molecular weight Hyaluronan and Hyaluronan oligosaccharides for wound healing with impaired vascularisation and immune system functioning is effective.
The role of hyaluronic acid fragments in immunity signalling has been proven both for innate and adhered immunity response.
Special applications: IVM and IVF fertilisationSpecial applications as an IMV of IVF fertilisation should be stressed. The effectiveness of the technique is increased when the ovum is de-coated with the use of LMW Hyaluronan and Hyaluronan oligosaccharides which is normally done due to the presence of hyaluronidase in sperm. In the later phase, pro-angiogenetic properties are utilised to support nesting and nourishment of the fertilised ovum in the uterus.