OligoHyaferre
OligoHyaferre consists of hyaluronan oligosaccharides with a molecular weight of less than 5000 Da. These short chains of disaccharide units occur naturally in the skin, where they engage in a wide spectrum of biological activity.
OligoHyaferre has these properties and, in view of its effects on internal processes in the skin, has proved to be a highly effective weapon in the fight against external signs of aging.
Wrinkles: In-vivo efficacy
Wrinkles, as the most obvious sign of aging skin, have their basis in both the epidermis and the dermis. In an in vivo study performed on 37 volunteers, OligoHyaferre demonstrated the ability to make a clear reduction in the scope and depth of wrinkles. Its ability to regulate the wrinkles was reflected not only in objective measurements, but also in the subjective perception of those individuals treated.
In-vivo effect of OligoHyaferre on wrinkles; upper before, lower after treatment.
Wrinkles: Mechanisms of action
OligoHyaferre actively contributes to the suppression of wrinkles in both layers of the skin.
At the level of the epidermis, its ability to stimulate the endogenous synthesis of high-molecular hyaluronan is manifested particularly well. This results not only in the augmentation of wrinkles through hydration of the epidermis, but also in the regulation of immune processes as described for high-molecular hyaluronan. Therefore, the cells and ECM are protected and negative wrinkle-inducing processes are controlled.
At the level of the dermis, OligoHyaferre is particularly good at suppressing the manifestation of proinflammatory interleukins (TNF-alpha). Excessive production of these substances triggers adverse developments in the immune response, producing, for example, increased quantities of free radicals capable of damaging both components of the extracellular matrix and the skin cells themselves.
Elasticity: In-vivo efficacy
Elasticity is a manifestation of skin aging, and its processes are very closely connected with wrinkling. It comes as no surprise, then, that during the in vivo study OligoHyaferre, besides its effect on wrinkles, was also shown to have a strong positive influence on the elasticity of the skin.
Combining several of the monitored parameters representing viscoelastic properties of skin, there was an almost 20% improvement in skin elasticity. This significantly adjusts the skin’s ability to resist mechanical deformation, which decreases as the skin ages.
Elasticity: Mechanisms of action
OligoHyaferre’s mechanism of action is based on support for the production of basic components of the extracellular matrix and on the stimulation of angiogenesis.
Hyaluronan oligomers boost the production of collagen, elastin and other components of the extracellular matrix by means of cells, thus contributing to the restoration of the basic structure of the skin and shaping its mechanical and viscoelastic properties.
OligoHyaferre has just as important an influence on the degradation processes, which it regulates by inhibiting matrix metalloproteases, thus preventing the degradation of ECM and checking the development of the chronic inflammations that may result from excessive MMP activity.
The support of angiogenesis in the skin is similarly essential for reliable functioning, reflected in appropriate mechanical parameters. Loss of the smallest capillaries and of the elasticity of the vascular wall, particularly evident in aging skin, has a negative impact due to the insufficient nutrition of skin cells and the accumulation of the metabolism’s waste products. The support of angiogenesis results in increased blood supply, the sufficient transport of nutrients promoting cell proliferation, and the synthesis and discharge of the metabolism’s waste products.
